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COMPARATIVE STUDIES OF THE CHROMOSOMAL ARRANGEMENT IN THE C-METAPHASE BETWEEN NORMAL KARYOTYPE AND TRISOMY-21
Chromosomal arrangements C-metaphase Radial & Homologue distances (+21) Satellite-association
2009/12/31
Human chromosomes in amnion cells and lymphocytes with normal karyotype and in lymphocytes with pathological karyotype (2n=47, +21) were compared as to their position in the metaphase. None of the col...
南京汉族群体肺癌易感性相关基因的研究Studies of the Genes Related to Lung Cancer Susceptibility in Nanjing Han Population, China
肺癌 代谢酶基因 多态性 遗传易感性
2008/1/8
摘要
为了探讨南京汉族群体肺癌易感性相关基因，我们采用1:1病例对照研究方法，以PCR—RFLP技术检测了152对肺癌和健康对照的CYP1A1、CYP2E1、GSTM1、GSTT1、GSTP1、mEH和NQO1基因的基因型并分析其与肺癌的相关性。结果发现携带CYP1A1突变基因型（wt/mt和mt/mt）的个体明显增加患肺鳞癌的风险(OR=2.31,95%CI=1.23-4.36)；GSTT1（...
摘要采用Penrose先证者同胞法和分离分析方法对72个家系资料的分析表明：卷舌、尖舌均为常染色体单基因显性遗传，阳性为显性性状；翻舌为常染色体单基因隐性遗传，阳性为隐性性状。虽然环境因素对这类特征的表现也有一定的影响，但遗传因素仍起主要作用。
Abstract:The data of 72 families were analyzed by the method of proband′s si...