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2017罕见和未诊断的疾病 Keystone Symposia（2017 Keystone Symposia on Rare and Undiagnosed Diseases: Discovery and Models of Precision Therapy）
Genome Sequencing Mendelian Disease Gene Discovery
2017/1/13
The meeting will begin on Sunday, March 5 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, March 8 with a closing plenary session...
Studies of the categorical perception (CP) of sensory continua have a long and rich history in
psychophysics. In 1977, Macmillan et al. introduced the use of signal detection theory to CP
studies. A...
Reconciling Predictive Coding and Biased Competition Models of Cortical Function
neural networks cortical circuits cortical feedback biased competition predictive coding
2015/7/29
A simple variation of the standard biased competition model is shown, via some trivial mathematical manipulations, to be identical to predictive coding. Specifically, it is shown that a particular imp...
NEUROPROTECTIVE STUDIES ON THE MPTP AND SOD1 MOUSE MODELS OF NEURODEGENERATIVE DISEASES
ALS MPTP SOD1 neurodegeneration
2015/5/21
The main, underlying cause of neurodegenerative disease is the progressive loss of neuronal structure or function, whereby central and/or peripheral nervous system circuitry is severely and irreversib...
Models of care for orphaned and separated children and upholding children’s rights: cross-sectional evidence from western Kenya
orphans Western Kenya
2014/12/11
Background Sub-Saharan Africa is home to approximately 55 million orphaned children. The growing orphan crisis has overwhelmed many communities and has weakened the ability of extended families to mee...
Researchers engineer 'Cas9' animal models to study disease and inform drug discovery
animal drug disease
2014/10/9
Cambridge, Mass. September 25th, 2014 — Researchers from the Broad Institute and Massachusetts Institute of Technology have created a new mouse model to simplify application of the CRISPR-Cas9 system ...
Mathematical Models to Assess Foot–Ground Interaction: An Overview
FORCE–DEFORMATION PATTERN SHOD FOOT MODEL BAREFOOT MODEL PLANTAR SOFT TISSUE
2017/7/17
The mechanical properties of the interface between the human body and the ground play an important role in attenuating the foot strike impact during locomotion. Understanding the properties of such an...
Rescuing a broken heart: A tale of two Models of Neural Crest deficiency and its impact on In Utero Heart function and Embryonic Survival via the Beta-Adrenergic pathway
pax3 beta-adrenergic embryonic cardiac function
2015/5/21
Congenital heart defects occur in approximately one percent of births every year, which makes it the most frequently occurring congenital defect in patients. The aim of this project was to use two mut...
Comparison of mass transfer models for determination of the intestinal permeability
Mass transfer Permeability Laminar flow Perfusion Mixing tank model
2009/12/18
Background and the purpose of the study: In determination of the permeability of the intestinal wall by external perfusion techniques, several models have been proposed. In the present study three mod...
Diabetic Complications in Experimental Models
Diabetes diabetic complications animal models insulin
2009/7/2
In this review, the aim is to focus on diabetic complications in experimental models of diabetis. For this purpose, com-plications, chiefly seen in log-term periods in various systems of animals, suc...
Enzyme-Linked Immunosorbent Assays with High Sensitivity for Antigen-Specific and Total Murine IgE: A Useful Tool for the Study of Allergies in Mouse Models
allergen-specific IgE blocking reagent enzyme-linked immunosorbent assay
2010/11/16
Enhancer solutions are effective in improving ELISAs for total and antigen-specific murine IgE. Selection of blocking reagents was important to decrease unwanted enhancement of background signals and ...
Forecasting Models for Sugi (Cryptomeria japonica D. Don) Pollen Count Showing an Alternate Dispersal Rhythm
annual pollen count dispersal rhythm forecasting model periodicity sugi (Cryptomeria japonica)
2010/11/17
An alternate pollen dispersal rhythm represented by a dummy variable in the multiple regression analysis plays a key role in improving forecasting models for the total annual sugi pollen count.
A Proposal Concept of a Polygene Network in Systemic Vasculitis: Lessons from MRL Mouse Models
autoantibody Cd72 collagen disease Fas genetic polymorphism
2010/11/18
In addition to the studies of cellular and molecular events in the pathogenesis of systemic vasculitis, a genome analysis of mouse models may shed some light on the complex clinicopathological manifes...
Effects of neuropeptides in the development of the atopic dermatitis of mouse models
atopic dermatitis calcitonin gene-related peptide neuropeptides olopatadine hydrochloride substance P
2010/11/22
It is suggested that repeated contact allergic dermatitis or mental stress may promote the development and exacerbation of AD and that substance P has a role in this response. In addition, it seems th...