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An 'environment to nucleus' signaling system operates in B lymphocytes: redox status modulates BSAP/Pax-5 activation through Ref-1 nuclear translocation
Ref-1 DNA-binding activity signaling
2014/12/12
The Ref-1 (also called APE or HAP1) protein is a bifunctional enzyme impacting on a wide variety of important cellular functions. It acts as a major member of the DNA base excision repair pathway. Mor...
Flow cytometric analysis of lymphocytes and lymphocyte subpopulations in induced sputum from patients with asthma
bronchial asthma CD4-positive lymphocyte flow cytometry induced sputum interleukin-2 receptor
2010/11/25
Study objectives were to compare the numbers of lymphocytes and lymphocyte subpopulations in induced sputum from asthmatic patients and from healthy subjects, and to determine the effect of inhaled an...
IL-13 GENE TRANSLATION IS ARRESTED BY A NOVEL OLIGONUCLEOTIDE IN CULTURED HUMAN B- LYMPHOCYTES
Antisense Human IL-13
2010/4/26
Antisense oligodeoxynucleotides (oligos) are the tools that bind to complemen¬tary sequence of targeted mRNA and block specifically protein translation. In the present study, a novel 20 mer oligo ...