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Omega-3 long-chain PUFA intake during pregnancy and allergic disease outcomes in the offspring: a systematic review and meta-analysis of observational studies and randomized controlled trials
allergic disease n–3 LC-PUFA pregnancy allergy prevention fatty acids randomized controlled trial prenatal supplementation asthma eczema hayfever
2018/11/23
Background: There is some evidence that increased maternal intake of omega-3 (n–3) long-chain polyunsaturated fatty acids (LC-PUFAs) during pregnancy may reduce the incidence of immunoglobulin E (IgE)...
Awarded Article, Annual Meeting of JSA Fibroblasts as Local Immune Modulators in Ocular Allergic Disease
conjunctiva cornea cytokine fibroblast vernal keratoconjunctivitis
2010/11/18
Vernal keratoconjunctivitis (VKC), a severe form of ocular allergic disease, is characterized by the formation of giant papillae at the upper tarsal conjunctiva and corneal lesions that threaten visio...
Cytokine and anti-cytokine therapy for the treatment of asthma and allergic disease
anti-interleukin-4 anti-interleukin-5 anti-tumor necrosis factor-α asthma cytokines
2010/11/22
Asthma is a chronic inflammatory disorder of the airways superimposed upon structural changes that include an increase in smooth muscle and airway wall remodeling. In addition to a background of chron...
Recent Developments in Genetic Study of Allergic Disease in the Japanese Population
allergic disease asthma atopy Japanese linkage polymorphism
2010/11/19
Allergy is a common immune disorder characterized by raised IgE levels, which leads to clinical disorders such as asthma, rhinitis and eczema. Our understanding of the pathogenesis of allergic disease...
IL-13/IL-13 Receptor Interaction, an Emerging Therapeutic Target in Allergic Disease
allergy antagonist asthma drug design interleukin-13 receptor
2010/11/19
Interleukin (IL)-13 is a Th-2 cytokine, known to be involved in allergic diseases. Although IL-13 and another Th-2 cytokine, IL-4, share receptors and signal pathways, having similar biological proper...