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探讨妊娠期高血压疾病患者血清N末端-脑钠肽前体(NT-proBNP)、内皮素-1 (ET-1)、一氧化氮(NO)水平及其临床意义。方法 选取上海市浦东新区人民医院2016年11月至2018年5月收治的妊娠期高血压疾病患者147例，根据其分型分为妊娠期高血压组84例和子痫前期组63例，另选取同期正常妊娠孕产妇60例作为对照组。采用电化学发光免疫法检测血清NT-proBNP水平，采用酶联免疫吸附法检测...
Astaxanthin has no effect on arterial stiffness, oxidative stress, or inflammation in renal transplant recipients: a randomized controlled trial (the XANTHIN trial)
carotid artery intima-media thickness F2-isoprostanes pentraxin-3 pulse wave velocity vascular function
2018/11/26
Background: There is evidence that renal transplant recipients have accelerated atherosclerosis that is manifest by increased cardiovascular morbidity and mortality. The high incidence of atherosclero...
探讨2型糖尿病早期肾病肾小球血管内皮生长因子-一氧化氮(VEGF-NO)轴失衡，血管内皮细胞功能障碍在2型糖尿病早期肾病发生中的作用。方法 将20只Wistar雄性大鼠随机分为正常对照组(NC组)和糖尿病肾病组(DN组)。NC组予普通饲料喂养，DN组予高糖高脂饲料喂养并腹腔注射小剂量链脲佐菌素(30 mg/kg)建立2型糖尿病肾病早期大鼠模型。造模成功后检测大鼠血糖(GLU)、血胰岛素(INS)、...
Should Guidelines for Conventional Hemodialysis Initiation in Acute Methanol Poisoning, Be Revised,When no Fomepizloe is Used?
Hemodialysis Methanol Poisoning
2015/9/28
Background: Consumption of home-distilled alcohol may lead to epidemic or sporadic cases of severe acute methanol poisoning. The difficulty of establishing strict indications for hemodialysis in acute...
肾上腺髓质素原N端20肽对血管紧张素刺激心肌成纤维细胞生成NO的影响
纤维细胞 肾上腺髓质素
2007/7/25
肾上腺髓质素(adrenomedullin, ADM)是1993年由Kitamura等[1]从肾上腺髓质瘤中发现的一种心血管活性肽，来源于其基因编码的肾上腺髓质素原(proadrenomedullin，proADM)。proADM 分子中的成对碱性氨基酸残基为内源性肽酶的加工位点。proADM在体内被酶解后生成4个肽段,分别为肾上腺髓质素原N端20肽(proADM N-terminal 20 pe...