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Pancreatic neuroendocrine tumours are rare tumours that can either present with syndromes from excess hormonal production or from mass effect – from the primary or metastases. They vary widely in clin...
Hypoxia is a condition in which an area of the body or a tissue is deprived of sufficient supply of oxygen. The lack of nutrients in a hypoxic tissue generally causes apoptosis but some cells are able...
Giant cell tumours (GCTs) of bone have been described as the most challenging benign bone tumors. It is very unusual for GCT to occur in patients younger than 20 yrs or older than 55 years. GCT is see...
Neuroendocrine tumours have posed a challenge for the development of research and management strategies because of their rarity and heterogeneity, both from clinical and molecular perspectives. Classi...
Metastatic cancers are often resistant to conventional chemotherapy and radiotherapy, reflecting an unmet need for novel therapeutic approaches to inhibit metastasis. Growing evidence highlights the i...
Circulating tumour cells – often referred to as a ‘liquid biopsy’ for cancer – can be found in a large proportion of patients with breast cancer that has spread to other organs. Changes in circulating...
Recent advances in genomic technology, in particular gene expression profiling, may elucidate novel tumour markers or signatures that will predict how various tumours will behave and respond to vario...
This paper reviews the evaluation of malignancy and prognostic parameters used in gastrointestinal stromal tumours (GIST). Incorporated is a case report of a duodenal GIST treated at our institutio...
Microarray-based transcript profiling is a technique used to measure the steady-state levels of gene expression on a genome-wide scale in a cell or tissue. The technology essentially involves making a...
With the rapid establishment of immunohistology as an indispensable adjunct to histological diagnosis, an ever-increasing range of antibodies has been developed to complement highly sensitive methods ...
The dendritic cell (DC), an uncommon type of bone marrowderived leukocyte, is widely acknowledged as the most effective antigen presenting cell (APC) and has the unique capacity to initiate and cont...
A new study by scientists at The University of Nottingham's Children's Brain Tumour Research Centre, funded by the Samantha Dickson Brain Tumour Trust, shows that prolonged and slow diagnosis can mak...
Solitary fibrous tumour (SFT) is a rare neoplasm first described in the pleura, but which may also arise from other serosal surfaces outside the pleura (1). The a etiology of SFT is unknown and usuall...
The authors report an autopsy case of a malignant peripheral nerve sheath tumour in a 9-year-old female Akito-ino dog, presenting as a pseudo aneurysm of the left jugular vein. Signs and symptoms in...

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