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Chronopharmacology is an important but under-explored aspect of therapeutics. Rhythmic variations in biological processes can influence drug action, including pharmacodynamic responses, due to ci...
Traditional titanium dioxide (TiO2) has photocatalytic bactericidal properties only under ultraviolet (UV) irradiation, which restricts its use in clinical treatment regimens. In this study, we evalua...
Obtaining ECAP recordings is also possible in the most apical region of the cochlea. However, differences can be observed depending on the region of the cochlea stimulated. Specifically, significant h...
In heart failure, QT interval and action potential duration (APD) is prolonged and IKs, a slow component of delayed rectifier potassium current, decreases. We have reported that the KCNE1 gene, coding...
Effects of eugenol compounds on the production of nitric oxide (NO) in RAW264.7 macrophages were analyzed in relation to the anti-inflammatory action of these compounds. Eugenol and isoeugenol inhib...
Computer models of the electrical and mechanical actions of the heart, solved on geometrically realistic domains, are becoming an increasingly useful scientific tool. Construction of these models requ...
Experimental results are commonly fitted by determining parameter values of suitable mathematical expressions. In case a relation exists between different data sets, the accuracy of the parameters obt...
The shunt resistance across the junctions produced by the gj-channels (Rgj) was varied from 100,000 MΩ (0 gj-channels) to 10,000 MΩ (1 gj-channel), to 1,000 MΩ (10 channels), to 100 MΩ (100 channels),...
We found a close association between increased APD dispersion and susceptibility to re-entrant arrhythmias, when APD dispersion is increased by larger spatial scale of heterogeneity, greater electroph...
Transverse propagation of excitation occurred at multiple points along the chain as longitudinal propagation was occurring, causing the APs in the contiguous chains to become bunched up. Transverse pr...

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