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Multi-scale analysis of morphology, mechanics, and composition of collagen in murine osteogenesis imperfecta
Atomic force microscopy Raman spectroscopy Reference point indentation MicroCT crystallinity modulus
2015/1/12
Osteogenesis imperfecta is a rare congenital disease commonly characterized by brittle bones caused by mutations in the genes encoding Type I collagen, the single most abundant protein produced by the...
Nanoscale Morphology of Type I Collagen is Altered in the Brtl Mouse Model of Osteogenesis Imperfecta
AFM nanoscale
2014/11/6
Bone has a complex hierarchical structure that has evolved to serve structural and metabolic roles in the body. Due to the complexity of bone structure and the number of diseases which affect the ultr...
Effects of tissue hydration on nanoscale structural morphology and mechanics of individual Type I collagen fibrils in the Brtl mouse model of Osteogenesis Imperfecta
AFM Ultrastructure Genotype/phenotype D-periodic spacing Modulus Energy
2014/11/6
Type I collagen is the most abundant protein in mammals, and is a vital part of the extracellular matrix for numerous tissues. Despite collagen’s importance, little is known about its nanoscale morpho...
Multi-scale Analysis of Bone Chemistry, Morphology and Mechanics in the oim Model of Osteogenesis Imperfecta
Atomic force microscopy Raman Spectroscopy Reference Point Indentation MicroCT Crystallinity Modulus
2014/11/6
Osteogenesis imperfecta is a congenital disease commonly characterized by brittle bones and caused by mutations in the genes encoding Type I collagen, the single most abundant protein produced by the ...
Multiscale analysis of morphology and mechanics in tail tendon from the ZDSD rat model of type 2 diabetes
AFM Tension Nanoscale Ultrastructure Modulus
2014/11/6
Type 2 diabetes (T2D) impacts multiple organ systems including the circulatory, renal, nervous and musculoskeletal systems. In collagen-based tissues, one mechanism that may be responsible for detrime...
The detailed anatomy of TMJ of sheep was explored so that it could be used as an experimental animal for study of condylar growth. The experimental animal was a 3 month old sheep, head of which was pr...
Influence of 2-methoxyestradiol on cell morphology and Cdc2 Kinase activity in WHCO3 esophageal carcinoma cells
2-methoxyestradiol cell morphology Cdc2 Kinase activity WHCO3 esophageal carcinoma cells
2009/3/2
The influence of 1 × 10-6 M exogenous 2-methoxyestradiol (2ME) was investigated on nuclear and cytoplasmic morphology, as well as Cdc (cell division cycle) 2 kinase activity in WHCO3 esophageal carc...
The effect of structural alterations of PEG-fibrinogen hydrogel scaffolds on 3-D cellular morphology and cellular migration
Tissue engineering Biosynthetic Fibrin Smooth muscle cells Polyethylene glycol
2010/1/7
The need for alternative scaffolds in tissue engineering has motivated the establishment of advanced biomaterial technologies based on
biosynthetic polymers. Networks of synthetic and biologic buildi...