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Circadian variations in liver gene expression: Relationships to drug action
Circadian variations liver gene expression drug action
2009/12/24
Chronopharmacology is an important but under-explored aspect of therapeutics. Rhythmic
variations in biological processes can influence drug action, including pharmacodynamic
responses, due to ci...
Imaging Multidimensional Therapeutically Relevant Circadian Relationships
Multidimensional Therapeutically Circadian
2009/9/4
Circadian clocks gate cellular proliferation and, thereby, therapeutically target availability within proliferative pathways. This temporal coordination occurs within both cancerous and noncancerous p...
Circadian expression of the Na+/H+ exchanger NHE3 in the mouse renal medulla
Circadian expression Na+/H+ exchanger NHE3 mouse renal medulla
2009/5/8
Renal tubular NHE3, the Na+/H+ exchanger, is a critical enzyme for electrolyte and acid-base homeostasis in the kidney. We previously demonstrated that the expression of this gene in the kidney foll...
Circadian expression of 86- and 84-kDa heat shock proteins in the mouse suprachiasmatic nucleus
Circadian expression 86- and 84-kDa heat shock proteins mouse suprachiasmatic nucleus
2009/3/2
Circadian rhythm pervades in many aspects of the biological processes including basic cellular functions. Here we examined the circadian gene expression of two forms of 90 kDa heat shock proteins re...