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New technology paves way towards personalized antibiotic therapy New sensor provides quick test to measure antibiotic resistance
microwave sensor antibiotics resistance bacteria
2021/8/10
Researchers have developed a method for monitoring bacterial responses to antibiotics in health-care settings that opens the door to personalized antibiotic therapy for patients. Using microwave sensi...
New study offers insight on how resistance training burns fat
resistance movement reduced fat adipocyte metabolism
2021/8/10
Findings from a new study add to growing evidence that resistance exercise has unique benefits for fat loss. Researchers found that resistance-like exercise regulates fat cell metabolism at a molecula...
New findings about cancer cell growth may hold promise for future cancer treatments
eIF4A3 growth of cancer cells treatment of cancer
2021/8/6
For a cell to grow and divide, it needs to produce new proteins. This also applies to cancer cells. Researchers have now investigated the protein eIF4A3 and its role in the growth of cancer cells. The...
When new mothers complain that all those sleepless nights caring for their newborns are taking years off their life, they just might be right. A year after giving birth, the 'biological age' of mother...
New genes linked to longer reproductive lifespan in women
CHEK1 CHEK2 new genes menopause DNA repair
2021/8/6
Scientists have identified nearly 300 gene variations that influence reproductive lifespan in women. Additionally, in mice, they have successfully manipulated several key genes associated with these v...
中科院上海药物研究所杨春皓研究组在进行新型抗肿瘤药物研发的同时，还积极致力于以生物活性为导向的杂环合成方法学研究，为研究组的新药发现奠定化学基础。研究组利用一些人们熟知的、简单易得的有机小分子（如苯乙腈类，邻羟基苯乙酮类——an old dog）为起始原料，发展新的方法（New tricks）用以快速构建结构多样的具有类药性的杂环化合物。
苯乙腈类化合物是一类人们熟知的重要有机化学及药物化学中间体（an old dog），如何利用这样简单的分子合成一些药物化学的优势结构或活性分子不但充满了吸引力，而且具有一定的挑战性。