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Risk factors for asthma and allergic diseases among 13-14-year-old schoolchildren in Japan
allergy asthma childhood International Study of Asthma and Allergies in Childhood prevalence risk factor
2010/11/24
In analyses of family histories, the odds ratios (OR) of children who have a family history with no symptoms were significantly lower by risk factor-based analyses compared with those children with a ...
Possibility of non-steroidal treatment in allergic conjunctival diseases
allergic conjunctival disease corticosteroid immunosuppressive agent non-steroidal anti-inflammatory drug vernal keratoconjunctivitis
2010/11/22
In a recent epidemiological study, 15-20% of the population in Japan was estimated to have allergic conjunctivitis. Allergic conjunctival diseases (ACD) have a wide spectrum of clinical severity and t...
Dinucleotide repeat polymorphisms in the signal transducers and activators of transcription 6 (Stat6) gene in children with allergic diseases
atopy dinucleotide repeat polymorphism interleukin-13 interleukin-4 signal transducers and activators of transcription 6 (Stat6)
2010/11/22
Background: Signal transducers and activators of transcription 6 (Stat6) is involved in the interleukin (IL)-4 and IL-13 signaling pathway. The aim of the present study was to evaluate whether polymor...
Role of dendritic cells in Th1/Th2 balance: A novel therapeutic target of allergic diseases
dendritic cell monocyte chemotactic protein-1 OX40 ligand regulatory T cells Th2
2010/11/22
Considerable evidence supports the role of dendritic cells (DC) in the pathogenesis of allergic diseases. Dendritic cells, as the most potent antigen-presenting cells (APC) for the induction of primar...
Th1, Th2, Tc1 and Tc2 cells of patients with otolaryngological diseases
acute sensorineural hearing loss Kimura's disease Meniere's disease Tc1 Tc2 Th1 Th2 Wegener's granulomatosis
2010/11/22
Cytokines are important regulatory mediators secreted by T cells and other immunoactive cells. Based on the cytokine synthesis patterns, CD4 T cells can often be classified into at least two populatio...
Pulmonary involvements caused by changes in peripheral perfusion in collagen-vascular diseases
collagen-vascular diseases diffusion capacity (DLco) drug-induced perfusion pulmonary hypertension pulmonary involvement vasculopathy
2010/11/22
Collagen-vascular diseases (CVD) involve many organs. Among organ involvements, pulmonary disorders may determine the prognosis of CVD. Because the vasculature and blood perfusion are commonly altered...
Concentrations of eosinophil-derived neurotoxin in the blood and urine of patients with allergic diseases
allergic rhinitis atopic dermatitis bronchial asthma eosinophil-derived neurotoxin eosinophil
2010/11/24
The median concentrations of EDN in blood and urine and the number of eosinophils in peripheral blood from patients with active symptoms were all significantly higher compared with values obtained whe...
Questionnaire-based Study on the Relationship between Pet-keeping and Allergic Diseases in Young Children in Japan
allergy asthma atopic dermatitis cats dogs Japan pet-keeping
2010/11/22
Background: It is still unclear how early exposure to pets is related to the risk of developing atopy-related diseases in children. There are few reports on this pet-allergy relationship in Japan alth...
Effects of Probiotics on the Immune System and Allergic Diseases
adaptive immunity allergic diseases commensals epithelial cells innate immunity intestinal microbiota probiotics
2010/11/22
Intestinal microbiota play a crucial role in the development of mucosal tolerance and adaptation. Perturbations in microbiota composition are strongly associated with allergies and asthma in westerniz...
Possible Roles of B1 Cells and Environmental Estrogens (Endocrine Disruptors) in the Development of Autoimmune Diseases
autoantibody B cell chemokine environmental estrogens SLE
2010/11/22
Autoimmune diseases as well as type-I allergic diseases have markedly increased in the past 30 years. Environmental estrogens or endocrine disruptors are possibly involved in the etiology of the incre...
Epstein-Barr Virus Infection in Childhood May Precipitate Atopic Diseases
atopic dermatitis atopy bronchial asthma Epstein-Barr virus infection
2010/11/22
Anti-EBV, in particular anti-EBNA antibody titer and AtLy count in peripheral blood were markedly higher in patients with bronchial asthma (BA) and/or atopic dermatitis (AD) than in non-atopic control...
Anti-TNF Biological Agents in Rheumatoid Arthritis and Other Inflammatory Diseases
Monoclonal antibody RA Receptor antagonist TNF
2010/11/19
It is now evident that biological agents targeting on the tumor necrosis factor (TNF) have not only induce a substantial clinical response, but also inhibit the structural damage in patients with Rheu...
CpG Oligodeoxynucleotides as a Future Vaccine for Allergic Diseases
antigen-specific bronchial asthma dendritic cell Th1/Th2 cell
2010/11/19
An astounding feature of the DNA sequences termed CpG motifs is the induction of immune and inflammatory responses in a senseless manner. CpG motifs exist abundantly in microbes and evoke innate immun...
CURRENT STATUS OF RESPIRATORY DISEASES SUFFERED BY JAPANESE PEOPLE LIVING IN SOUTHEAST ASIA
Japanese people living abroad Respiratory diseases Air pollution
2010/12/10
We gathered and analyzed date on respiratory diseases suffered by Japanese adults treated in Ram Hospital in Chiang Mai and Subang Jaya Medical Center in Kuala Lumpur. In both hospitals, the percentag...
AIRBORNE FUNGI IN INDUSTRIAL ENVIRONMENTS - POTENTIAL AGENTS OF RESPIRATORY DISEASES
airborne fungi poultry house swinery
2010/12/24
Investigations on airborne fungi in a poultry house, a swinery, a feed preparing and storing house, a grain mill, a wooden panel producing factory, and organic waste recycling facilities have been car...