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浙江大学生命科学研究院2022年1月17日沈立实验室在Leukemia合作发文解析HMCES对长期造血干细胞的保护作用并提出白血病治疗的新靶点（图）
沈立 造血干细胞 白血病治疗 新靶点
2022/10/25
长期造血干细胞（long-term hematopoietic stem cell, LT-HSC）通过自我更新和多向分化维持机体的终身造血。在稳态下，这群稀有的成体干细胞通过保持静息状态以减少活性氧（ROS）的产生从而保证其基因组的稳定性。然而，当遭受造血压力刺激时，LT-HSC会退出静息状态并快速活化和增殖，从而导致细胞内的ROS水平迅速升高，进而产生无碱基位点（AP位点）等DNA氧化损伤。当...
Xenotropic Murine Leukemia Virus-Related Virus and RNase L R462Q Variants in Iranian Patients With Sporadic Prostate Cancer
Xenotropic Murine Leukemia Virus-Related Virus Polymorphism RNase L Prostate Cancer
2015/12/29
Background: Although several studies have confirmed the association of xenotropic murine leukemia virus-related virus (XMRV) and prostate cancer, this association is still controversial, as most studi...
Chronic Myeloid Leukemia with Variant Chromosomal Translocations:Results of Treatment with Imatinib Mesylate
Chronic myeloid leukemia Imatinib Variant translocation
2015/7/10
Objective: To evaluate the efficacy of imatinib in chronic myeloid leukemia patients with variant translocations. Methods: Forty eight chronic myeloid leukemia patients carrying variant translocations...
ERK1 AND ERK2 IN HEMATOPOIESIS, MAST CELL FUNCTION, AND THE MANAGEMENT OF NF1-ASSOCIATED LEUKEMIA AND TUMORS
hematopoiesis neurofibroma leukemia
2015/5/25
Neurofibromatosis type 1 is a genetic disease that results from either heritable or spontaneous autosomal dominant mutations in the NF1 gene, which encodes a protein serving, at least in part, to acce...
ZAP70 Expression Within del6q21, del11q13 and del17p13 Cytogenetic Subgroups of Iranian Patients with Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia ZAP70 Expression Chromosomal Abnormality
2015/10/15
Background: B-cell chronic lymphocytic leukemia (B-CLL) is the most common form of leukemia in adults. Some reports showed that expression of ZAP70 gene and chromosomal abnormality are two prognostic ...
Juvenile Myelomonocytic Leukemia (JMML) is rare, fatal myeloproliferative disease (MPD) affecting young children, and is characterized by expansion of monocyte lineage cells and hypersensitivity to Gr...
FISH Analysis for del6q21 and del17p13 in B-cell Chronic Lymphocytic Leukemia in Iranians
Leukemia Lymphocytic Chronic B-Cell Cytogenetic Aberrations Biological Markers
2015/9/29
Background: B-cell chronic lymphocytic leukemia (B-CLL) is the most common leukemia in the Western world. Major progress has been made in assessing typical chromosomal abnormalities and recognition of...
Successful Treatment of Life-Threatening Cerebral Bleeding Associated with Disseminated Intravascular Coagulation Using Recombinant Human Soluble Thrombomodulin in a Patient with Mixed Phenotype Acute Leukemia with t (9; 22) (q34; q11.2); Bcr-Abl1
Mixed Phenotype Acute Leukemia with t (9 22) (q34 q11.2) Bcr-Abl1
2013/1/29
Recently, mixed phenotype acute leukemia (MPAL) with t (9; 22) (q34; q11.2); bcr-abl1 was described as one kind of acute leukemia of ambiguous lineage in the 2008 World Health Organization Classificat...
Obesity and childhood survivors of acute lymphoblastic leukemia: Do genetics play a role?
Genetic Polymorphisms Obesity Metabolic Syndrome Acute Lymphoblastic Leukemia
2013/1/30
Childhood survivors of acute lymphoblastic leukemia (ALL) are increased risk of several chronic complications, such as second cancers, pulmonary, metabolic complications and cardiovascular disease. Ob...
Guillain-Barré-like Syndrome,as a Rare Presentation of Adult T-cell Leukemia-Lymphoma (ATLL):A Case Report
Guillain-Barré Syndrome Human T-lymphotropic virus 1 Leukemia-Lymphoma Adult T-Cell
2015/9/28
We report a 21-year-old woman who was admitted because of unilateral facial paresis and then developed progressive ascending flaccid tetraparesis with generalized areflexia. Electrodiagnostic studies ...
Correlates of Age at Initial Diagnosis of Chronic Lymphocytic Leukemia: Exercise, ASA & Emotional Distress
Chronic Lymphocytic Leukemia Stress Aspirin
2013/8/30
Objective: No studies of either the cross-sectional or prospective association of behavioral lifestyle characteristics and the onset of Chronic Lymphocytic Leukemia (CLL) exist. Methods: Multiple inte...
Correlates of Age at Initial Diagnosis of Chronic Lymphocytic Leukemia: Exercise, ASA & Emotional Distress
Chronic Lymphocytic Leukemia Stress Aspirin
2013/1/31
Objective: No studies of either the cross-sectional or prospective association of behavioral lifestyle characteristics and the onset of Chronic Lymphocytic Leukemia (CLL) exist. Methods: Multiple inte...
Maternal and Prenatal Risk Factors for Childhood Leukemia in Southern of Iran
Leukemia Children Risk factors Prenatal Genetics
2015/9/23
Background: The causes of childhood leukemia as the most common malignancy in children are vastly unknown. The aim of this study is to evaluate the relationship between maternal birth characteristics ...
Initial Presentation of Acute Lymphoblastic Leukemia with Osteoporosis and Multiple Spontaneous Bone Fractures
Acute lymphoblastic leukemia Osteoporosis Bone fracture Iran
2015/9/22
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Skeletal abnormalities have been described in association with ALL including osteoprosis and bone fractures. Different facto...
Association between MDR1 C3435T Gene Polymorphism and Acute Lymphoblastic Leukemia (ALL) in Iranian Population
P-glycoprotein MDR1 Acute lymphoblastic leukemia C3435T polymorphism
2015/9/21
Background: P-glycoprotein (P-gp), an ATP-dependent efflux pump, is a membrane protein encoded by MDR1 gene. P-gp has an important role in protection of the cell against xenobiotics and toxic compound...