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肝细胞癌是常见的恶性肿瘤之一，其发病率和病死率一直居高不下。目前肝细胞癌的首选治疗方法为手术治疗及肝移植，但5年生存率仍较低，且由于肝细胞癌起病隐匿，大多数患者初期均无特殊表现，确诊时已经处于终末期，失去手术机会。Hh通路在肿瘤的发生、发展中发挥关键作用，锌指蛋白GLi作为Hh通路中的关键转录因子在肿瘤的发生中起着重要作用。同时锌指蛋白GLi可通过诱导上皮\|间质转化的发生,从而在肝细胞癌的侵袭转...
Gli-2 在胸腺肿瘤组织中的表达及其与Ki-67的关系
Gli- 2 胸腺肿瘤 Ki-67 预后 免疫组织化学
2015/7/6
探讨Gli- 2 蛋白和核增殖标志物Ki-67与胸腺肿瘤的临床病理特征及预后的关系。方法：采用免疫组织化学方法，检测64例胸腺肿瘤（9 例A 型、6 例AB型、11例B 1 型、22例B 2 型及16例C 型）组织中Gli- 2 及Ki-67蛋白的表达情况。结果：1）Gli- 2 在胸腺瘤A 、AB、B 1、B 2、C 型的阳性率分别为1/ 9（11.11%）、2/ 6（33.33%）、2/ 11...
CORRECTION OF SENSOR ALIGNMENT OF ADEOS-II/GLI
Photogrammety Geometric Accuracy Optical Sensor Correction
2015/5/29
The Advanced Earth Observing Satellite (ADEOS)-II was successfully launched in December 2002 by Japan Aerospace and Exploration Agency (JAXA: former NASDA). The Global Imager (GLI) onboard the ADEOS-I...
The GLI (Global Imager) on board the ADEOS-II is an optical mechanical scanner with 36 channels and the spatial resolution of 1 km and 250m at nadir. It is the successor of the ADEOS/OCTS (Ocean Color...
Overlapping and distinct functions for Gli proteins: Key mediators of hedgehog signaling in cell specification during embryonic development
Signals embryonic tissue cell differentiation the central nervous system the pituitary gland the pancreas cells
2014/12/11
Hedgehog (Hh) signaling is important for patterning and cell differentiation within many embryonic tissues. Hh is expressed in the notochord and the floor plate and acts as a morphogen in patterning o...
Regulation of the Hypothalamic Precursor Cells by HH/GLI Signaling in Post-Embryonic Zebrafish
Biological sciences Health and environmental sciences Heat-shock Hedgehog signaling Hypothalamus Neurogenesis Transgenic
2014/12/10
The major goals of my research were to characterize the hypothalamic neural progenitors and to understand how Hh/Gli signaling plays a role in regulating cell proliferation in the hypothalamic neuroge...
Gli转录因子与肿瘤
Hedgehog Gli 转录因子 肿瘤
2014/5/29
Hedgehog（HH）信号通路参与胚胎发育、成人组织再生及修复，且在肿瘤细胞生长及转移过程中发挥重要作用。已有大量研究证实该信号通路的异常激活与多种肿瘤的发生发展密切相关。Gli是HH通路直接调控靶基因的转录因子，是该通路不同水平激活的最后共同通道，在致瘤过程中起着重要作用。Gli受多通路多因素调节，故抑制Gli靶向性治疗具有非常广阔的前景。本文对Hedgehog-Gli信号通路在恶性肿瘤发生发...
TGF-β对KG-1细胞株Gli 2表达影响
KG-1细胞 转化全长因子-β(TGF-β) SIS3 Gli 2
2014/8/6
探讨在白血病KG-1细胞株中转化生长因子-β(transforming growth factor-β,TGF-β)信号通路对Gli的调控作用。方法 用0.1、1、10 ng/mL TGF-β1分别作用于KG-1细胞6、12和24 h,收集细胞,提取mRNA,检测Gli 2表达;5 ng/mL TGF-β1、5 ng/mL TGF-β1+5μmol/L SIS 3(specific inhibit...
Preface of special issue on GLI and AMSR。
Hedgehog-Gli信号传导通路在脑肿瘤中的研究进展
Hedgehog-Gli 脑肿瘤 神经干细胞 脑肿瘤干细胞
2009/1/19
脑肿瘤，特别是恶性脑肿瘤的治疗目前仍是临床医生面临的一个难题，重要的原因之一是由于对脑肿瘤的发生发展机制尚不明了。最新研究表明：神经干细胞、脑肿瘤干细胞都可能参与这一过程，针对干细胞水平的研究将给脑肿瘤的治疗带来新希望。Hedgehog-Gli信号通路正是一条影响干细胞生物学行为的重要通路。本文就该通路在神经系统发育、神经干细胞分化和脑肿瘤发生的研究作一综述。
Aerosol and Cloud Validation System Based on SKYNET Observations : Estimation of Shortwave Radiation Budget Using ADEOS-II/GLI Data
GLI SKYNET validation radiation budget
2010/11/23
Using ADEOS-II/GLI aerosol and cloud products, downward and upward solar radiation at the surface and at the top of the atmosphere are estimated to study the Earth radiation budget. There is a good ag...
Retrieval Algorithm Based on Combined Use of POLDER and GLI Data for Biomass Aerosols
Aerosols AOT POLDER-2 GLI ADEOS-2
2010/11/23
A procedure for aerosol retrieval by combining data provided by POLDER (Polarization and Directionality of the Earth's Reflectances) and GLI (Global Imager) sensors mounted on the ADEOS-2 satellite (A...
Estimating and Validating the Net Primary Production of Vegetation using ADEOS-II/GLI Global Mosaic and 250-m Spatial Resolution Data
cedar forest field validation global net primary production Global Imager
2010/11/23
High-accuracy estimation of the net primary production (NPP) of vegetation is important in the study of the carbon cycle and the biotic response to climatic warming. This study estimated the NPP of ve...
Global Land Cover Classification using ADEOS-II/GLI Global Mosaic Data
ADEOS-II/GLI global mosaic data sets land cover classification UPDM MVIUPD
2010/11/23
This paper describes the algorithm used to produce a global land cover product using data sets from the second Advanced Earth Observing Satellite/Global Imager (ADEOS-II/GLI). Although ADEOS-II was in...
Ocean Color Research for Global Imager (GLI) on Advanced Earth Observation Satellite-II (ADEOS-II)
ocean color chlorophyll primary production coastal environment red tide
2010/11/23
Advanced Earth Observation Satellite-II (ADEOS-II) was launched on December 14, 2002, and it operated from April to October 2003. One of the core sensors of ADEOS-II is Global Imager (GLI) which measu...