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Inhibition of sweet chemosensory receptors alters insulin responses during glucose ingestion in healthy adults: a randomized crossover interventional study
sweet taste receptors lactisole glucose intolerance insulin saccharin artificial sweeteners OGTT modeling analysis
2018/11/13
Background: Glucose is a natural ligand for sweet taste receptors (STRs) that are expressed on the tongue and in the gastrointestinal tract. Whether STRs directly contribute to the regulation of gluco...
Peroxisome proliferator-activated receptors: a family of lipid-activated transcription factors
differentiation fatty acids fatty acid synthase
2016/6/1
Peroxisome proliferator-activated receptors
(PPARs) are a family of nuclear transcription factors that belong
to the steroid receptor superfamily. This family of PPARs includes
PPARa, PPARd, PPARg1...
Opioid-induced hypophagia is mediated by 5-HT2c receptors in neonatal layer-type chicken
opioidergic 5-HTergic system food intake layer-type chicks
2015/10/9
Opioidergic and serotonergic (5-HTergic) systems have crucial role in central regulation of food intake. This study was designed to investigate the role of the opioidergic system and the interaction w...
Effects of vitamin D3 on expression of defensins, Toll-like receptors, and vitamin D receptor in liver, kidney, and spleen of Silky Fowl
vitamin D3 induction chicken avian β-defensins real-time PCR
2015/6/24
The expression of avian β-defensins (AvBDs), Toll-like receptors (TLRs), and vitamin D receptor (VDR) following in vivo vitamin D3 injection was studied. Healthy 90-day Silky Fowls were abdominally in...
Role of Adenosine A1 Receptors in Native Coronary Atherosclerosis, In-stent Stenosis, and Coronary Blood Flow Regulation in Metabolic Syndrome and Exercise
Aldosterone Coronary heart disease Exercise
2015/5/22
Adenosine is widely thought to elicit coronary vasodilation and attenuate smooth muscle cell (SMC) proliferation, thereby providing cardioprotection. We cloned the porcine adenosine A1 receptor (A1R) ...
Sphingosine 1-phosphate enhances excitability of sensory neurons through sphingosine 1-phosphate receptors 1 and/or 3
sphingosine 1-phosphate S1P excitability sensory neurons G protein-coupled receptors
2015/5/21
Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid that has proven to be an important signaling molecule both as an extracellular primary messenger and as an intracellular second messenger. Ext...
ELUCIDATING MECHANISMS THAT LEAD TO PERSISTENT ANXIETY-LIKE BEHAVIOR IN RATS FOLLOWING REPEATED ACTIVATION OF CORTICOTROPIN-RELEASING FACTOR RECEPTORS IN THE BASOLATERAL AMYGDALA
anxiety corticotropin-releasing factor somatostatin amygdala basolateral amygdala
2015/5/21
Anxiety disorders are estimated to impact 1 in 4 individuals within their lifetime. For some individuals, repeated episodes of the stress response leads to pathological anxiety and depression. The str...
Effect of polychlorinated biphenyls on the secretion of oxytocin from luteal and granulosa cells in cow: possible involvement of glucocorticoid receptors
polychlorinated biphenyls oxytocin glucocorticoid receptors ovary cow
2015/3/5
Polychlorinated biphenyls (PCBs) stimulate oxytocin secretion from bovine granulosa and luteal cells. Since oxytocin on the one hand is released from ovarian cells by cortisol and on the other hand PC...
Alpha adrenergic receptors are involved in the contractile activity of neuropeptide Y in the porcine isolated ovarian artery
neuropeptide Y α-adrenergic agonists α-adrenergic antagonists norepinephrine porcine ovarian artery blood pressure
2015/1/27
The objective of this study was to determine whether α-adrenergic receptors are involved in the contractile activity of neuropeptide Y (NPY) in the porcine isolated ovarian artery collected from immat...
Investigating the role of extrasynaptic GABAA receptors located in the infralimbic cortex in the binge-like alcohol intake of male C57BL/6J mice
Mouse Alcohol GABA Binge Drinking Infralimbic Cortex
2015/1/9
Extrasynaptic GABAA receptors, often identified as those containing both α4 and δ subunits, appear to be a target for the actions of alcohol (ethanol) at relatively low concentrations, perhaps suppres...
Forward and Reverse Genetic Approaches to Studying Locomotor Behavior: atp2a1 and Gaba a Receptors in the Zebrafish Embryo
Forward and reverse genetic approaches to studying locomotor behavior: Atp2a1 and GABAA receptors in the Zebrafish embryo
2014/11/4
Excitation and inhibition in the nervous system must be carefully balanced. I utilized the zebrafish (Danio rerio) in order to study this balance in the vertebrate motor system. Zebrafish (Danio rerio...
Complement Receptors
补体受体 Complement Receptors
2014/6/24
Complement receptors are membrane proteins expressed on the surface of immune cells.They interact specifically with complement factors leading to the removal of antigen from the circulation.
The Expression of Leptin, Estrogen Receptors, and Vitellogenin mRNAs in Migrating Female Chum Salmon, Oncorhynchus keta: The Effects of Hypo-osmotic Environmental Changes
Chum Salmon Estrogen Receptors Leptin Maturation Salinity Change Vitellogenin
2016/5/16
Leptin plays an important role in energy homeostasis and reproductive function in fish, especially in reproduction. Migrating fish, such as salmonoids, are affected by external environmental factors, ...
The effects of metabotropic glutamate receptors in NMDA receptor dependent long-term potentiation in hippocampus
NMDA metabotropic glutamate hippocampus
2014/3/31
The previous study has showed that LTP in CA1 region of hippocampus is NMDA receptor dependent. It is evoked by extracellular calcium enter intopyramidal neuron and the further responds is caused by ...
Self-Organized Criticality in Proteins: Hydropathic Roughening Profiles of G-Protein Coupled Receptors
Proteins: Hydropathic Roughening Profiles G-Protein Coupled Receptors
2010/11/24
Proteins appear to be the most dramatic natural example of self-organized criticality (SOC), a concept that explains many otherwise apparently unlikely phenomena. Protein conformational functionality ...