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Structural insights into Arabidopsis ethylene response factor 96 with an extended N-terminal binding to GCC box
AP2/ERF ERF 96 GCC box EDLL motif Protein structure Fluorescence polarization assay
2024/1/11
The phytohormone ethylene is widely involved in many developmental processes and is a crucial regulator of defense responses against biotic and abiotic stresses in plants. Ethylene-responsive element ...
Multifunctional novel rosin derivatives based on dehydroabietylamine with metal ion sensing and DNA/BSA binding activities
Rosin derivative DNA binding BSA interaction Metal ion recognition
2023/12/6
Three novel rosin derivatives based on dehydroabietylamine which is an important modified product of rosin,?pyridine?and substituted phenol were synthesized and fully characterized. The DNA binding st...
A Picea wilsonii NAC transcription factor, PwNAC1, interacts with RNA-binding protein PwRBP1 and synergistically enhances drought and salt tolerance of transgenic Arabidopsis
Picea wilsonii Transcription factor PwNAC1 PwRBP1 Abiotic stress ABA signaling
2023/11/16
NAC transcription factors play crucial roles in plant resistance to a variety of adverse circumstances. Here, we characterized a NAC transcription factor PwNAC1 from Picea wilsonii and subcellular loc...
A human neutralizing antibody targets the receptor binding site of SARS-CoV-2
Preventive medicine SARS-CoV-2 Viral infection
2020/6/11
An outbreak of the coronavirus disease 2019 (COVID-19)1–3, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)4 spread globally. Countermeasures are needed to treat and prevent ...
Key Residues of the Receptor Binding Motif in the Spike Protein of SARS-CoV-2 That Interact With ACE2 and Neutralizing Antibodies
SARS-CoV-2 cross-neutralizing antibody receptor binding motif spike protein substitution mutation
2020/6/11
Coronavirus disease 2019 (COVID-19), caused by the novel human coronavirus SARS-CoV-2, is currently a major threat to public health worldwide. The viral spike protein binds the host receptor angiotens...
Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody
2019-nCoV SARS-CoV ACE2 monoclonal antibody RBD
2020/6/12
The newly identified 2019 novel coronavirus (2019-nCoV) has caused more than 11,900 laboratory-confirmed human infections, including 259 deaths, posing a serious threat to human health. Currently, how...
Breaking the Binding: Attacks on the Merkle Approach to Prove Liabilities and its Applications
proof of liabilities Maxwell protocol summation Merkle tree
2018/11/30
Proofs of liabilities are used for applications, function like banks or Bitcoin exchanges, to prove the sums of money in their dataset that they should owe. The Maxwell protocol, a cryptographic proof...
Binding language: Structuring sentences through precisely timed oscillatory mechanisms
alpha and beta oscillations EEG language syntactic binding
2018/3/5
Syntactic binding refers to combining words into larger structures. Using EEG, we investigated the neural processes involved in syntactic binding. Participants were auditorily presented two-word sente...
Next-gen sequencing identifies non-coding variation disrupting miRNA binding sites in neurological disorders
SCZ ASD
2017/8/28
Understanding the genetic factors underlying neurodevelopmental and neuropsychiatric disorders is a major challenge given their
prevalence and potential severity for quality of life. While large-scal...
Adjusting retinol-binding protein concentrations for inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project
anemia inflammation meta-analysis nutritional assessment retinol-binding protein vitamin A deficiency
2018/11/15
Background: The accurate estimation of the prevalence of vitamin A deficiency (VAD) is important in planning and implementing interventions. Retinol-binding protein (RBP) is often used in population s...
Demographic, lifestyle, and genetic determinants of circulating concentrations of 25-hydroxyvitamin D and vitamin D–binding protein in African American and European American women
African American European American racial disparity vitamin D vitamin D–binding protein
2018/11/14
Background: Vitamin D may have anticancer activities. The high prevalence of vitamin D deficiency in African Americans (AAs) may be a contributing factor to the cancer health disparities between AAs a...
Genetic effects of sterol regulatory element binding proteins and fatty acid-binding protein4 on the fatty acid composition of Korean cattle (Hanwoo)
Fatty Acid-binding Protein4 (FABP4) Single-Nucleotide Polymorphism (SNP)
2017/3/8
This study identifies single-nucleotide polymorphisms (SNP) or gene combinations that affect the flavor and quality of Korean cattle (Hanwoo) by using the SNP Harvester method.
Retinol binding protein as a surrogate measure for serum retinol: studies in vitamin A–deficient children from the Republic of the Marshall Islands
retinol retinol binding protein RBP
2016/6/13
Serum retinol is transported by retinol binding protein
(RBP), which has one high-affinity binding site for retinol;
consequently, the molar ratio of retinol to RBP in the circulation
is 1 to 1. In...
Biochemical but not clinical vitamin A deficiency results from mutations in the gene for retinol binding protein
Retinol binding protein transthyretin retinol retinyl esters
2016/5/31
Two German sisters aged 14 and 17 y were admitted
to the Tübingen eye hospital with a history of night blindness.
In both siblings, plasma retinol binding protein (RBP) concentrations
were below th...
Mutations in the gene encoding retinol binding protein and retinol deficiency: is there compensation by retinyl esters and retinoic acid?
retinyl esters retinoic acid
2016/5/31
Biesalski et al (1) present a novel case of 2 sisters aged 14 and
17 y with very low plasma retinol concentrations (0.19 mmol/L)
and plasma concentrations of retinol binding protein (RBP) below
the...