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LPL基因突变与高甘油三酯血症相关性研究进展
脂蛋白脂酶 高甘油三酯血症 冠心病 基因突变
2014/4/3
高甘油三酯血症是导致动脉硬化和冠心病的主要危险因素之一。近年来研究发现除了环境饮食因素外，遗传因素在高甘油三酯血症、动脉硬化和冠心病的发生过程中起重要作用。脂蛋白脂酶(LPL)作为脂质代谢的关键酶，主要催化乳糜微粒和极低密度脂蛋白中的甘油三酯水解，释放游离脂肪酸供机体利用。大量研究表明高甘油三酯血症、糖尿病和冠心病患者都存在LPL基因突变。在高甘油三酯血症患者中LPL常见的基因突变主要是Asp9A...
Polymorphism of LPL Locus in Japanese and Comparison of PCR Amplification Efficiency from Degraded DNA between LPL Locus and the D21S11
Short tandem repeat (STR) LPL Japanese population D21S11 Degraded DNA
2010/1/21
The short tandem repeat (STR) polymorphism of the lipoprotein lipase (LPL) locus was amplified by PCR and analyzed using denaturing polyacrylamide gel electrophoresis followed by silver staining. Amon...
Polymorphism of LPL Locus in Japanese and Comparison of PCR Amplification Efficiency from Degraded DNA between LPL Locus and the D21S11
Short tandem repeat LPL Japanese population
2010/12/1
The short tandem repeat (STR) polymorphism of the lipoprotein lipase (LPL) locus was amplified by PCR and analyzed using denaturing polyacrylamide gel electrophoresis followed by silver staining. Amon...