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Inhibition of sweet chemosensory receptors alters insulin responses during glucose ingestion in healthy adults: a randomized crossover interventional study
sweet taste receptors lactisole glucose intolerance insulin saccharin artificial sweeteners OGTT modeling analysis
2018/11/13
Background: Glucose is a natural ligand for sweet taste receptors (STRs) that are expressed on the tongue and in the gastrointestinal tract. Whether STRs directly contribute to the regulation of gluco...
Peroxisome proliferator-activated receptors: a family of lipid-activated transcription factors
differentiation fatty acids fatty acid synthase
2016/6/1
Peroxisome proliferator-activated receptors
(PPARs) are a family of nuclear transcription factors that belong
to the steroid receptor superfamily. This family of PPARs includes
PPARa, PPARd, PPARg1...
Sphingosine 1-phosphate enhances excitability of sensory neurons through sphingosine 1-phosphate receptors 1 and/or 3
sphingosine 1-phosphate S1P excitability sensory neurons G protein-coupled receptors
2015/5/21
Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid that has proven to be an important signaling molecule both as an extracellular primary messenger and as an intracellular second messenger. Ext...
ELUCIDATING MECHANISMS THAT LEAD TO PERSISTENT ANXIETY-LIKE BEHAVIOR IN RATS FOLLOWING REPEATED ACTIVATION OF CORTICOTROPIN-RELEASING FACTOR RECEPTORS IN THE BASOLATERAL AMYGDALA
anxiety corticotropin-releasing factor somatostatin amygdala basolateral amygdala
2015/5/21
Anxiety disorders are estimated to impact 1 in 4 individuals within their lifetime. For some individuals, repeated episodes of the stress response leads to pathological anxiety and depression. The str...
Complement Receptors
补体受体 Complement Receptors
2014/6/24
Complement receptors are membrane proteins expressed on the surface of immune cells.They interact specifically with complement factors leading to the removal of antigen from the circulation.
IL-33 and IL-33 Receptors in Host Defense and Diseases
allergy autoimmunity basophil chronic disease eosinophil host defense IL-33 mast cell ST2
2010/11/12
Interleukin-33 (IL-33) is a member of the IL-1 cytokine family, which includes IL-1 and IL-18. IL-33 is considered to be crucial for induction of Th2-type cytokine-associated immune responses such as ...
P2X7 Receptors in Neurological and Cardiovascular Disorders
Neurological Cardiovascular Disorders
2009/9/3
P2X receptors are ATP-gated cation channels that mediate fast excitatory transmission in diverse regions of the brain and spinal cord. Several P2X receptor subtypes, including P2X7, have the unusual p...
P2X7 Receptors as a Transducer in the Co-Occurrence of Neurological/Psychiatric and Cardiovascular Disorders: A Hypothesis
P2X7 Receptors Neurological/Psychiatric
2009/9/3
Background. Over-stimulation of the purinergic P2X7 receptor may bring about cellular dysfunction and injury in settings of neurodegeneration, chronic inflammation, as well as in psychiatric and cardi...
Possible Role of Platelet GluR1 Receptors in Comorbid Depression and Cardiovascular Disease
Cardiovascular Disease Platelet GluR1 Receptors
2009/9/3
The exact nature of the comorbidity between cardiovascular disease (CVD) and major depressive disorder (MDD) is poorly understood. The proposed mechanisms include various biochemical and molecular pat...
Immunohistochemical Expression of C-Erb-B2, Steroid Receptors and Cathepsin-D in Breast Carcinomas: A Clinicopathologic Trial
Breast carcioma cathepsin-D c-erb-B2
2009/6/29
Aim: We investigated the role of c-erb-B2, hormone receptors and cathepsin D in breast carcinoma progression and their correlation with each other. Methods: Forty-six breast carcinoma patients, operat...
Acute Stress Ameliorates Colitis via Central Corticotropin- Releasing Factor and Serotonin (5-HT)-3 Receptors
Colitis serotonin stress HPA axis sympathetic nervous system
2009/6/23
The central nervous system may modulate many aspects of inflammation through alterations of the autonomic nervous system and/or the hypothalamo-pituitary-adrenal (HPA) axis. The aim of present study w...
Medial Expression of TNF-α and TNF Receptors Precedes the Development of Atherosclerotic Lesions in Apolipoprotein E/LDL Receptor Double Knockout Mice
atherosclerosis lipoproteins TNF-α TNF receptors
2009/4/20
TNF-α is present in atherosclerotic lesions, activates endothelial adhesion molecule expression, stimulates the release of proinflammatory cytokines and matrix metalloproteinases and promotes smooth ...
Muscarinic and 5-HT4 receptors participate in the regulation of the frequency of spontaneous contractions of the longitudinal muscle in rat distal colon
Muscarinic 5-HT4 receptors participate spontaneous contractions longitudinal muscle
2009/3/3
Spontaneous contractions of the intestine are thought to play an important role in the gastrointestinal motility, including peristalsis. In the present study, we investigated mechanisms for regulati...
Prostaglandin facilitates afferent nerve activity via EP1 receptors during urinary bladder inflammation in rats
Prostaglandin facilitates EP1 receptors urinary bladder inflammation rats
2009/3/2
We examined the effects of loxoprofen, a cyclooxygenase inhibitor, and ONO-8711, an EP1-receptor antagonist, on afferent nerve activity during acetic acid (AA, 0.1% v/v)-induced inflammation of the ...
Effect of a neuraminidase inhibitor（oseltamivir）on mouse jump-down behavior via stimulation of dopamine receptors
neuraminidase inhibitor mouse jump-down behavior stimulation of dopamine receptors
2009/3/2
Oseltamivir (Tamiflu®, Roche Laboratories, Inc.) is a neuraminidase inhibitor that can cause jumpdown behaviors in children. There is a mouse slip-down model, in which the dopamine D2 receptor a...