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人类内源性逆转录病毒（Human endogenous retrovirus, HERV）是一类由远古逆转录病毒整合于生殖细胞基因组而形成的转座子元件，大约占人类基因组的8%。由于进化过程中产生的序列突变和宿主的表观遗传抑制，大多数HERV失去了正常的表达能力。而现阶段越来越多的研究发现，部分HERV的表达在人类生长发育中具有重要的生理功能。因此，系统阐明HERV的表达分布规律和调控机制，将为理解...
Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells
APE1/Ref-1 cell signaling difference analysis
2014/12/12
Apurinic apyrimidinic endonuclease/redox effector factor 1 (APE1/Ref-1) protects cells from oxidative stress by acting as a central enzyme in base excision repair pathways of DNA lesions and through i...
Heterogeneity of 3’-Untraslated Region of Genome RNA of the Tick-Borne Encephalitis Virus (TBEV) Strains Isolated from Ticks in the Western Siberia, Russia
deletions hemagglutination neurovirulence reverse transcription–polymerase chain reaction
2009/4/20
The tick-borne encephalitis virus (TBEV) strains have been isolated from unfed adult ticks Ixodes persulcatus Schulze in Novosibirsk region (South-Western Siberia, Russia) beginning from 1980 till 200...
Overlapping of Genes in the Human Genome
overlapping genes human genome locus exon chromosome
2009/4/20
Overlapping genes are relatively common in DNA and rNA viruses. there are several examples in bac-terial and eukaryotic genomes, but, in general, overlapping genes are quite rare in organisms other th...
Detection of Microsatellite Alterations in Plasma DNA of Malignant Mucosal Melanoma Using Whole Genome Amplification
Free-circulating DNA Plasma DNA Loss of heterozygosity
2010/12/1
Malignant mucosal melanoma (MMM) still has the poorest prognosis. There is a paucity of molecular biological studies on MMM of the head and neck. We investigated free-circulating DNA microsatellites w...
Detection of Tumor DNA in Plasma Using Whole Genome Amplification
Malignant melanoma, Adenoid cystic carcinoma Loss of heterozygosity (LOH) Plasma or serum DNA Circulating tumor DNA
2010/1/20
Altered microsatellite DNA in the blood of cancer patients may provide a novel means for tumor detection. Such alterations are a major characteristic of many types of tumor especially those associated...
Detection of Tumor DNA in Plasma Using Whole Genome Amplification
Malignant melanoma Adenoid cystic carcinoma
2010/12/1
Altered microsatellite DNA in the blood of cancer patients may provide a novel means for tumor detection. Such alterations are a major characteristic of many types of tumor especially those associated...
Translation of the human genome into clinical allergy
asthma atopy genome microarray transcriptome
2010/11/24
By complete reading of the genome sequence, in the near future we will be able to determine the role of genomic DNA sequence variation among individuals, such a single nucleotide polymorphism (SNP), i...
Translation of the human genome into clinical allergy, part 2
basophils mast cells microarray system biology transcriptome
2010/11/22
After completion of sequencing of the human genome, you will no longer be able to discover a new gene and may not be able to find a new molecule in the human body. Instead, you may find many new molec...
The Human Genome Project: Assessing Confidence in Knowledge and Training Requirements for Community Pharmacists
Human Genome Project genetic testing pharmacogenomics knowledge community pharmacists
2018/3/15
Objectives. This study evaluated community pharmacists' confidence in their knowledge regarding the advances in the human genome project (HGP) and determined their requirements for education and train...
Eating behavior in the Old Order Amish:heritability analysis and a genome-wide linkage analysis
Restraint obesity behavioral genetics Amish heritability linkage analysis
2016/12/17
Background: Eating behavior and thus dietary intake affect the development of obesity-related diseases such as diabetes, hypertension, and hyperlipidemia.Objective: We investigated the genet...