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浙江大学生命科学研究院2022年1月17日沈立实验室在Leukemia合作发文解析HMCES对长期造血干细胞的保护作用并提出白血病治疗的新靶点（图）
沈立 造血干细胞 白血病治疗 新靶点
2022/10/25
长期造血干细胞（long-term hematopoietic stem cell, LT-HSC）通过自我更新和多向分化维持机体的终身造血。在稳态下，这群稀有的成体干细胞通过保持静息状态以减少活性氧（ROS）的产生从而保证其基因组的稳定性。然而，当遭受造血压力刺激时，LT-HSC会退出静息状态并快速活化和增殖，从而导致细胞内的ROS水平迅速升高，进而产生无碱基位点（AP位点）等DNA氧化损伤。当...
Chronic Myeloid Leukemia with Variant Chromosomal Translocations:Results of Treatment with Imatinib Mesylate
Chronic myeloid leukemia Imatinib Variant translocation
2015/7/10
Objective: To evaluate the efficacy of imatinib in chronic myeloid leukemia patients with variant translocations. Methods: Forty eight chronic myeloid leukemia patients carrying variant translocations...
Juvenile Myelomonocytic Leukemia (JMML) is rare, fatal myeloproliferative disease (MPD) affecting young children, and is characterized by expansion of monocyte lineage cells and hypersensitivity to Gr...
Guillain-Barré-like Syndrome,as a Rare Presentation of Adult T-cell Leukemia-Lymphoma (ATLL):A Case Report
Guillain-Barré Syndrome Human T-lymphotropic virus 1 Leukemia-Lymphoma Adult T-Cell
2015/9/28
We report a 21-year-old woman who was admitted because of unilateral facial paresis and then developed progressive ascending flaccid tetraparesis with generalized areflexia. Electrodiagnostic studies ...
Initial Presentation of Acute Lymphoblastic Leukemia with Osteoporosis and Multiple Spontaneous Bone Fractures
Acute lymphoblastic leukemia Osteoporosis Bone fracture Iran
2015/9/22
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Skeletal abnormalities have been described in association with ALL including osteoprosis and bone fractures. Different facto...
The Prevalence and Clinical Significance of Anticardiolipin Antibody in Acute Myeloblastic Leukemia
Anticardiolipin antibody Acute myeloblastic leukemia Clinical significance Iran
2015/9/21
Background: Antiphospholipid antibodies, including lupus anticoagulants and anticardiolipin (aCL) antibodies are associated with a wide variety of disorders including malignancies. The aim of this stu...
Juvenile Dermatomyositis Associated with Acute Lymphocytic Leukemia
Juvenile dermatomyositis Leukemia Leukemia Malignancy
2009/7/3
A link between dermatomyositis and neoplasia has long been suspected. The precise incidence of this association remains controversial, owing to varying criteria used to diagnose dermatomyositis. Altho...
Blood and Fingernail Copper (Cu) and Magnesium (Mg) Levels of Children With Acute Lymphoblastic Leukemia
Leukemia copper magnesium fingernail
2009/7/3
In this study, serum and fingernali Cu and Mg levels of 10 children with acute Iymphoblastic leukemia and 12 healthy children were determined. Copper and magnesium levels of the sera and supernatants...
Autologous stem cell transplantation with moderate dose of Idarubicin and Busulphan as conditioning regimen in acute myelogenous leukemia
Acute myeloid leukemia Stem cell transplantation Idarubicin Busulphan
2015/9/11
Background: Over 50% of patients with AML still relapse after autologous stem cell transplantation. We investigated the efficacy and feasibility of a new conditioning regimen consisting of a moderate ...
Prevalence of chronic hepatitis in children with leukemia, 1996-2001: a single center experience
Hepatitis B Hepatitis C Leukemia Lymphoma Children Cancer
2015/9/9
Background: There is a risk of viral hepatitis for children with leukemia. Both hepatitis B and C virus infections cause major problems in the management of leukemic patients. In this study, we evalua...
HLA Class II Allele and Haplotype Frequencies in Iranian Patients with Acute Myelogenous Leukemia and Control Group
Acute Myelogenous Leukemia HLA class II Polymorphism
2010/2/8
Previous studies have demonstrated some significant differences in HLA allele frequencies in leukemic patients and normal subjects. We have analyzed HLA class II alleles and haplotypes in 60 Iranian p...
Spontaneous production of interleukin-5 and its heterogeneous effect on eosinophils in an adult T-cell leukemia patient
adult T-cell leukemia eosinophil heterogeneity interleukin-5
2010/11/25
We examined the functional heterogeneity of eosinophils from an adult T-cell leukemia (ATL) patient with eosinophilia. A 63-year-old man was admitted to our hospital because of lymphadenopathy. The le...
PATHOLOGIC FRACTURE OF THREE EXTREMITIES AS FIRST SIGN OF ACUTE LYMPHOBLASTIC LEUKEMIA
multiple fracture radiologic finding
2010/4/2
Acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer representing 80-85% of all leukemia. We describe a 3 years old girl with pain, swelling and tenderness in extremities sin...
Flowcytometric and DNA Analysis Minimal Residual Disease (MRD) in Childhood B-Lineage lymphoblastic leukemia
Minimal Residual Disease DNA analysis
2010/5/7
Background: Induction Chemotherapy for Acute Lymphoblastic Leukemia achieves complete remis¬sion in over 90% of children. It is apparent therefore that many patients in clinical remission and with...
Treatment of acute myeloid leukemia (AML):Recent results and new directions
Acute myeloid leukemia hematopoietic stem cell transplantation
2010/5/7
Acute myeloid leukemia (AML) is a major indication for hematopoietic stem cell transplantation (HSCT). Here we describe more in general the present status and new directions in the therapy for AML.